Endocrine Abstracts

Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease in which the insulin-producing pancreatic beta-cells in the islets of Langerhans are destroyed. While the symptoms of the disease have become treatable to a certain extent, even intensive state-of-the-art insulin therapy cannot prevent the development of severe complications in the majority of patients. There is, therefore, a huge and unmet clinical demand for disease intervention, but a cure for T1D does not yet ex...

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) influences the differentiation and cytokine secretion of various immune cell types. These immune modulating effects of 1,25(OH)2D3 are mediated through the nuclear vitamin D receptor (VDR). In the immune system, the 1,25(OH)2D3/VDR complex interacts with promoter vitamin D responsive elements (VDRE), or interferes with the signalling of other transcription factor...